I have been taking a half dose of methotrexate Friday evenings (obviously I skipped a dose the weekend of the Reliant shows). Even at half a dose I feel like shi!t. Wake up on Saturdays in a pool of sweat, but freezing at the same time. And nauseous, plus diarrhea. And did I mention my skin is breaking out like crazy? And the joint pain always seems way worse for a couple of days after I take methotrexate. Next appointment with the Rheumatologist is this Tuesday, so maybe I can get off this junk and back to Enbrel.